GLP-1 Blood Panel Cheat Sheet: The 8 Numbers Every Man Should Track

GLP-1 medications affect far more than your weight.

The Data

Track these 8 numbers to see the full picture of what's changing in your body. Total Testosterone: target above 300 ng/dL (ideally 450–900). ENDO 2026 showed GLP-1s normalize T in 77% of obese men within 18 months.

What This Means for You

Test baseline, 6 months, 12 months. Free Testosterone: the fraction that's biologically active. Should be 9–25 pg/mL for men under 50. Total T alone is misleading without free T.

The Practical Application

Hemoglobin A1C: measures 3-month average blood sugar. Even non-diabetic men should track this — GLP-1s significantly improve insulin sensitivity. Target below 5.7%. Lipid Panel (total cholesterol, LDL, HDL, triglycerides): GLP-1 weight loss dramatically improves lipid profiles. Target LDL below 100, HDL above 40. ALT/AST (liver enzymes): monitors liver function. GLP-1s have emerging evidence for MASH/NAFLD improvement. Baseline is important since elevated enzymes may contraindicate certain treatments. Creatinine/eGFR (kidney function): especially important during the rapid weight loss and dehydration risk that GLP-1s create. Baseline and 6-month recheck. High-Sensitivity CRP (inflammation): systemic inflammation marker that correlates with cardiovascular and cancer risk. Should decrease with weight loss. Track baseline and 12 months. Vitamin D: most men are deficient. Supports testosterone production, immune function, bone health. Target 40–60 ng/mL. Supplement 2,000–4,000 IU daily..

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