GLP-1 + Creatine + Protein: The Evidence-Based Male Supplement Stack

Men on GLP-1 medications face a specific supplement challenge: preserving muscle mass while eating fewer calories with suppressed appetite.

The Data

Here's the evidence-based stack. Creatine monohydrate (5g daily): the most studied supplement in sports science. Improves resistance training performance, supports lean mass preservation during caloric restriction, and has emerging neuroprotective evidence.

What This Means for You

No loading phase needed. Protein (1.0–1.2g/kg daily): whey or plant-based, whatever hits the number. On GLP-1 appetite suppression, shakes often work better than solid protein. Vitamin D3 (2,000–4,000 IU daily): supports testosterone production and immune function.

The Practical Application

Most men are deficient. Electrolytes: GLP-1 medications can cause dehydration through reduced fluid intake (you're not as thirsty) and GI side effects. Sodium, potassium, magnesium daily. Magnesium (400mg glycinate before bed): supports sleep, recovery, and testosterone. What to skip: fat burners (you don't need them on GLP-1s), testosterone boosters (the medication itself restores T through weight loss), and appetite suppressants (redundant)..

Providers Worth Considering