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Sperm Quality on GLP-1s: What the Clinical Trials Actually Show

June 18, 2026 · GLP-1 Men Research Desk
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The ENDO 2026 meta-analysis from Warwick Medical School reviewed every published RCT on GLP-1 receptor agonists and male reproductive function.

The Data

The headline: GLP-1s do not harm sperm production and may improve it. Trial-by-trial breakdown: a 24-week semaglutide study showed improved sperm morphology (shape) and maintained testosterone and gonadotropins. A liraglutide maintenance study showed improved sperm concentration and total count.

ENDO 2026
Latest peer-reviewed evidence on GLP-1 medications and men's health

What This Means for You

A 16-week liraglutide trial in functional hypogonadism showed increased total testosterone, LH, and FSH — confirming the improvements come from restored natural production, not external hormones. Compare this to TRT, which causes 60.6% decrease in sperm concentration and is used as a male contraceptive in some countries. For men planning families now or in the future, GLP-1 treatment is the fertility-preserving choice..

The Practical Application

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Providers Worth Considering

Bodybuilding.com GLP-1
Semaglutide, Tirzepatide
Contact for pricing
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Found Health
Semaglutide
From $199/mo
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Care Bare Rx
Semaglutide, Tirzepatide
From $199/mo
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⚠️ FDA Compounding Notice: Compounded medications are not FDA-approved. They are prepared by pharmacies to meet individual patient needs. The FDA does not verify the safety, efficacy, or quality of compounded drugs.
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication.

Related from the Dispatch

ENDO 2026: GLP-1s & Male Fertility
GLP-1 vs. TRT: The 2026 Evidence