The common fear: "Won't GLP-1s lower my testosterone?" The research says the opposite. For obese men, GLP-1s appear to restore testosterone by reducing the fat tissue that was suppressing it.
The ENDO 2025 study from Saint Louis University found that 77% of obese men with low testosterone achieved normal levels after GLP-1 treatment — up from just 53% at baseline. Total testosterone increased from 312 to 368 ng/dL (P<.001). This wasn't a side effect of the medication; it was the result of losing visceral fat that was suppressing the HPG axis.
Obesity and low testosterone create a vicious cycle. Fat tissue converts testosterone to estrogen, which signals the brain to produce less testosterone, which makes it harder to lose fat. GLP-1s break this cycle.
Evidence-based deep dives into how GLP-1s affect testosterone, fertility, and the male hormonal axis.
The landmark study that changed the conversation about GLP-1s and male hormones.
âš¡ ResearchLjubljana study shows GLP-1s improved sperm quality while TRT destroyed it.
GuideTimeline, predictors, and what to do if your T doesn't recover naturally.
GuideFor men whose testosterone doesn't normalize — is combining treatments safe?
âš¡ ResearchItalian ENDO 2025 study: Tirzepatide outperformed TRT for testosterone and ED.
ExplainerWhy total T isn't the whole picture — and how GLP-1s affect free testosterone.
Compare GLP-1 telehealth providers — including ones that offer TRT if your testosterone doesn't normalize naturally.